![]() Hence, it is urgent to explore the etiological therapy of anti-NMDAR encephalitis. ![]() However, even after receiving timely immunotherapy, about 15.9% of patients still experience one or more long-term relapses, especially female patients. Although multiple researchers have reported treatment methods related to anti-NMDAR encephalitis, immunotherapy remains the pivotal clinical treatment contributing to a full recovery for patients at present. The common clinical manifestations include psychiatric disturbances, cogniti impairments (executive functions and memory), epileptic seizures, and somnipathy. ![]() These data involve various hippocampal neurons, which delineate a framework for understanding the hippocampal neuronal circuit and the potential molecular mechanisms of anti-NMDAR encephalitis.Īnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuropsychiatric disease caused by the antibody-mediated autoimmune response against NMDAR. Therefore, the above genes were used as potential targets for further research on the pathological process of anti-NMDAR encephalitis. Notably, the latter two molecules exhibited opposite changes in different models. Kcnq1ot1 in inhibitory neurons and Meg3 in interneurons also changed. In addition, we found that ATP metabolism and biosynthetic regulators related genes in excitatory neurons of DG subregion were significantly affected. ![]() Dramatic changes in cell proportions and differentially expressed genes were observed in excitatory neurons of the dentate gyrus (DG) subregion. Here, we construct the active and passive immunization mouse models of anti-NMDAR encephalitis, and use single-nucleus RNA sequencing to investigate the diverse expression profile of neuronal populations isolated from different hippocampal regions. Anti-NMDAR encephalitis mainly affects the hippocampus, however, its effect on gene expression in hippocampal neurons is unclear at present. ![]() The underlying molecular underpinnings of this disease are rarely characterized on a genomic scale. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuropsychiatric disease with variable clinical manifestations caused by NMDAR autoantibody. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |